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Friday, May 15, 2020 | History

4 edition of Peptide growth factors and their receptors 2 found in the catalog.

Peptide growth factors and their receptors 2

Peptide growth factors and their receptors 2

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Published by Springer-Verlag in New York, London .
Written in English


Edition Notes

Statementeditors: Michael B. Sporn and Anita B. Roberts.
ContributionsSporn, Michael B. 1933-, Roberts, Anita B., Battey, James F.
The Physical Object
Paginationxxviii,727p.
Number of Pages727
ID Numbers
Open LibraryOL22282173M
ISBN 100387976949, 0387977295, 3540976949, 3540977295

  An experimental peptide stimulates bone acquisition in female rats who have had their ovaries removed, raising the prospect a new drug for -2 is an insulin-like growth factor Cited by: 1. Epidermal Growth Factors (EGF) and Analogs (1) Fibroblast Growth Factors (FGF), Fragments and Related Peptides (4) Basic Fibroblast Growth Factor (FGF) Inhibitory Peptides (1) Insulin-Like Growth Factors (IGF), Fragments and Related Peptides (7) Platelet-Derived Growth Factors (PDGF) and Related Peptides (2).

The role of growth factors in development has been supported by studies in mouse and other species showing that a range of polypeptide growth factor ligands are produced by the reproductive tract and preimplantation embryo, while many of their receptors can be detected on the embryo surface 9. References. 1. Aloe L (). Rita Levi-Montalcini Missing: book. To address this issue, we have engineered an epidermal growth factor receptor (EGFR) targeting (with GE11 peptide) self-assembly amphiphilic peptide nanoparticle (GENP) to co-deliver gemcitabine and the PARPi olaparib to treat BRCA mutant PCa. The GENP was relatively stable, exhibited high encapsulation efficiency, and could coordinately Cited by: 5.

  Overview of tissue expression and actions of VIP. VIP is a basic amino acid peptide that was first extracted from pig small intestine and is expressed in numerous metabolically active organs such as the intestines, pancreas, urogenital tract, thyroid, adrenal glands, and the hypothalamus [2–4].VIP is highly conserved across many different animal phyla, suggesting an important function for Cited by: Peptide receptors belong to the A and B classes of GPCRs, constituting a large group of receptors that are activated by extracellular protein or peptide ligands. Endogenous peptide receptor ligands bind to the N-terminus and/or the three extracellular loops of the receptor. The peptide receptor-binding domains are large, conferring highMissing: book.


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Peptide growth factors and their receptors 2 Download PDF EPUB FB2

This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors.

Peptide Growth Factors and Their Receptors II | SpringerLink. Peptide growth factors and Peptide growth factors and their receptors 2 book receptors. Handbook of pharmacology. Volume parts 1 and 2 Edited by M.

Sporn and A. Roberts. Heidelberg: Springer-Verlag. pp (Part 1) and pp (Part 2). DM Author: Charles A. Dinarello. This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors.

Although there have been many symposia on this topic, and numerous publications of reviews dealing. The coordinate actions of sets of growth factors and their role in controlling fundamental processes that pertain to many different cells and tissues are also dealt with.-The peptides described here are of fundamental importance for understanding the behavior of all cells, and they will be of major importance in the practice of clinical medicine in the years to come F.

Regulation of Cell Surface Ligand Binding.- G. Transmembrane Domains.- H. Cytoplasmic Tyrosine Kinase Domain Structures.- I. Regulation of Receptor Tyrosine Kinases.- J.

Cytoplasmic Domains Lacking Tyrosine Kinase Sequences.- K. Conclusions.- References.- Section B: Peptide Growth Factors and Their Receptors I.- 4 The Epidermal Growth Factor.

This two-volume treatise represents a survey of the chemistry and biology of the set of molecules known as peptide growth factors.

These substances are of universal importance in biology and medicine and are the basis of common language of intercellular communication. The seven plenary sessions emphasized Peptides, Growth Factors, Peptide Receptors, Growth Factor Receptors, Second Messengers, Proliferation, and Clinical Correlations.

The chapters in this volume are derived from each of these scientific sessions plus the poster and special sessions. This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors.

Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the. Peptide growth factors Graham Carpenter and Stanley Cohen Interaction of growth factors with target cells involves the rapid internalization of ligand:receptor complexes.

The receptor possesses intrinsic tyrosyl protein kinase activity which may, in part, mediate the biological activities of the peptide g: book. PDGF is the major protein growth factor in human serum and is a markedly heat-stable, cationic protein that consists of two related but nonidentical (% amino-acid sequence identity) polypeptide chains designated A and B (also called PDGF-1 and PDGF-2).1,2 PDGF molecules exist as AA and BB homodimers, as well as an AB heterodimer.7 All of the ligands of the PDGF family exhibit similar Cited by: 3.

Receptors are modular proteins that can bind growth factors with high affinity and can transmit the information generated by binding into changes in cellular biochemistry. Growth factors also interact with other cell-associated or secreted binding by: 1. Journals & Books; Register Sign in.

Vol Issue 3, JulyPages Epidermal growth factor-related peptides and their receptors in human malignancies A.F. WilksProtein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer.

Adv Cancer Res, 60 (), pp. Cited by: Purchase Peptide Growth Factors, Part C, Volume - 1st Edition. Print Book & E-Book. ISBNBesides the receptors themselves, a number of endogenous cellular proteins as well as a variety of exogenous proteins and peptides serve as substrates for the growth factor-stimulated protein tyrosine kinases.

Synthetic peptides with defined sequences serve as substrates for the growth factor-stimulated tyrosine kinases. Peptide growth factors and their receptors serve as the major molecular signaling system in orchestrating tumor survival, growth, and interactions with the microenvironment.

Aberrant expression of these factors by tumor cells confers growth advantage and competence for metastasis either by autocrine or paracrine by: The intestinal tissues express a variety of peptide growth factors that modulate several functional properties of different intestinal cell populations, including the intestinal epithelium and lamina propria cell populations.

These peptide growth factors are characterized by relatively low molecular weight of less than 25 kDa, and they generally exert their effects through binding to specific Author: Jaladanki N. Rao, Jian-Ying Wang. The binding of IGF to its receptors leads to their dimerization and autophosphorylation in a conventional manner common to peptide growth factors.

Signaling pathways activated downstream generate the phenotypic changes of promotion of cell proliferation and survival and inhibition of apoptosis. The transmembrane receptors that bind to the FGF ligands have an intracellular domain that has tyrosine kinase activity.

This is activated by the binding of FGF. Activated receptors phosphorylate tyrosines on various target proteins and autophosphorylates tyrosine residues within their own intracellular g: book.

Peptide Hormones and Growth Factors. The widest variety of signaling molecules in animals are peptides, ranging in size from only a few to more than a hundred amino acids. This group of signaling molecules includes peptide hormones, neuropeptides, and a diverse array of polypeptide growth by: 2.

Bowen-Pope DF, Vogel A, Ross R. Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

Proc Natl Acad Sci U S A. Apr; 81 (8)– [PMC free article]Cited by:. A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins.

Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell to grow and/or superfamily: Platelet-derived growth factor, A.

Growth factors and wound healing: Biochemical properties of growth factors and their receptors * Author links open overlay panel MD Neil T. Bennett 1 PhD Gregory S. Schultz 2. Show more. Peptide growth factors have been shown to regulate many of these processes in vitro, Cited by:   Published: 03 January The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.

D. P. Barlow 1Cited by: